Xiaflex for Peyronie’s Disease: Cost, Uses, Dosage, Side Effects and Alternatives

Peyronie’s Disease is a very common condition that most men have suffered from, hence bringing them physical pain and emotional discomfort. Chapter 2 presented Xiaflex as part of the many newly-out treatment modalities in the market. Anyone who is looking to pursue this form of treatment should be privy to details from cost to the route of administration. With this comprehensive guide on Xiaflex, you will get all the details you need when making a decision.

What is Xiaflex?

Overview of Xiaflex

Xiaflex is a prescription medication, indicated to treat Peyronie’s Disease. This is a biologic drug in which collagenase clostridium histolyticum is used to break down the collagen that results in the characteristic plaque of Peyronie’s Disease.

What it is and How it Works

Xiaflex works on the collagenous buildups in the penis that are held responsible for such an atypical curvature. By being active in the degradation of this collagen, Xiaflex then helps bring back an appropriate alignment of elements in the penis and, by this, its functionality and the way it looks.

FDA Approval Process and Its Significance

The FDA approved Xiaflex for therapeutic usage of Peyronie’s Disease in 2013. This is a huge progressive step since it gives validity to the claims of effectiveness and safety for Xiaflex, based on that intense testing and the rows of clinical trials it passed through.

Uses of Xiaflex for Peyronie’s Disease

How Xiaflex Works in the Treatment of Peyronie’s Disease

Xiaflex is injected into the penile plaque. This is a localized approach, which ensures the medication works precisely at the point where it is needed.

How it Works to Reduce Plaque

The enzyme in Xiaflex known as collagenase breaks down the digestion of the collagen in the plaque, reducing it so that the plaque is softened and eventually reduced, Making the penis straighter and easing the symptoms reducing with Peyronie’s disease.

Expected Outcomes and Benefits

By administering Xiaflex, a significant number of patients tangibly believe that their penile curvature improves and sexual function normalizes, which for many people is a real benefit.

Dosage and Administration

Typical Dosage: Injections are normally delivered in a series. Each patient is, in most cases, treated for a maximum of four cycles, and within each cycle, two injections.

How Xiaflex is Administered

Injection Process

Xiaflex is injected directly into the plaques of the penis through a simple and minimally invasive treatment in an outpatient setting.

Treatment Schedule and Duration

The injections are usually done in a cycle, and thereafter, penile modeling exercises are done to exploit the treatment to the maximum. The whole treatment takes months for it to be complete.

Cost of Xiaflex

Factors Affecting the Cost of Xiaflex

Xiaflex could vary in cost, depending on one’s location of consultation, the costing of such healthcare providers, and how many treatment cycles were required.

Insurance Settlement

Some insurance plans cover Xiaflex under certain conditions. One would have to ask the insurance to understand what is covered.

Out-of-Pocket Expenses

Xiaflex is a medication that, without insurance, can be very expensive. Patients may face such out-of-pocket costs for this medication, and they should discuss with their doctor means of payment.

Average Cost Range

The average total cost of a full-course treatment is currently in the range of $20,000 to $30,000.

Comparison with Other Treatment Options

Comparing it with surgical options or other drugs, one can say it is cost-effective because it is a noninvasive procedure that can be done in the outpatient setting.

Side Effects of Xiaflex

Common Side Effects

Patients may experience some side effects such as pain, swelling, or bruising at the point of injection, but these are usually mild and transient.

Rare but Serious Side Effects

Some of the very rare severe side effects on allergies or even penile fracture may occur, but these require immediate medical attention.

What to Do if Side Effects Occur

Most side effects can be treated with over-the-counter pain medication and rest. However, if severe effects occur, get in touch with your healthcare provider.

When to Contact a Doctor

Call the doctor if ear pain is severe or if drainage occurs, with major swelling, or if the skin is red and it is really painful right around the ear.

Alternatives to Xiaflex

Other Treatment Options for Peyronie’s Disease

Other treatments include Xiaflex, oral medications, surgery, and lifestyle changes.


This, however, is less effective than Xiaflex and may include oral medications such as pentoxifylline and vitamin E supplements.


Surgeries like penile plication, grafting, and even penile implants can be considered in severe cases.

Lifestyle Changes and Physical Therapy

Other lifestyle changes, such as smoking cessation, as well as physical therapy exercises, could be generally helpful in penile health maintenance, supporting other forms of treatment.

Pros and Cons of Each Alternative

Each of these treatment modalities has its pros and cons. Medications are less invasive but can be less effective. Surgery is perhaps somewhat more definitive but at the cost of increased risks and recovery time. Lifestyle changes bring with them no risks, but their support in achieving suitable improvements is rather limited.


Xiaflex provides a valid alternative in nonsurgical applications to conventional modern pharmaceutical remediation for Peyronie’s Disease. It shows excellent improvement rates with regard to reduction of penile curvature and quality of life. Seeing a healthcare provider is a key point that will help define the treatment plan that is most effective for individual needs. All treatment options are put forward for exploration and, therefore, effective decisions can be made by the debilitated patient regarding his health.


1. Can Xiaflex be used by all?
Not at all. Xiaflex appears to work the best in those patients with a stable variety of Peyronie’s Disease and significant penile curvature. There is a need to consult a healthcare provider about suitability.

2. How does Xiaflex compare with other treatment options?
Xiaflex can be very effective with most patients, providing a nonsurgical option to achieve quite a bit of curvature reduction. However, in broader terms, its efficacy varies, and sometimes some patients can best be treated by a surgical or other approach.

3. What are some common potential side effects of Xiaflex?
Common adverse reactions associated with the procedure usually involve pain, swelling, and bruising at the point of injection. These are generally mild and temporary events.

4. Is Xiaflex going to be paid for by insurance?
It depends on every insurance company. It is important that you ask your provider what cost might be covered, and what out of pocket you might incur.

5. How long does one protocol last?
Each treatment cycle involves two injections and modeling procedures, which usually pass through multiple weeks of procedures. Multiple cycles are conducted for obtaining optimal results.

6. What should I do if I have a severe side effect?
Promptly consult with your healthcare professional if you experience any high-impact side effect or any sign of a hypersensitivity reaction.

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